热门文章 at IgMin Research

Nanotechnology, particularly nanorobotics, has emerged as a transformative force in modern medicine. Nanorobots, designed at the molecular scale, hold promise for a range of medical applications, including targeted drug delivery, early disease diagnostics, minimally invasive surgeries, and precise infection control. Their unique ability to interact with biological systems at the cellular level opens avenues for significant advancements in treatment protocols, potentially overcoming current limitations in traditional therapies. This review delve...s into the development, mechanisms, and diverse medical applications of nanorobots, highlighting their structural components, energy sources, and propulsion methods. Additionally, we explore specific case studies in cancer treatment, infection control, and surgical innovations, assessing both the advancements and challenges associated with nanorobotic technologies. The goal is to present a comprehensive overview that underscores the potential of nanorobots to revolutionize patient care and set the stage for future research in this burgeoning field.Read more

The astronomical theory of ice ages is widely accepted. Yet, it is not abundantly clear just exactly what the astronomical theory of ice ages is, other than the vague statement that variations in the Earth's orbit produce changes in solar irradiance at northern latitudes which is somehow related to the formation and termination of ice ages. Periodic variations in the Earth’s orbit produce variations in the insolation at high latitudes and ice ages begin on down lobes of insolation and terminate on up lobes of insolation. However, not all ...down lobes create ice ages and not all up lobes produce terminations. The ice ages changed character at the so-called mid-Pleistocene transition, about a million years ago. There is no current physical explanation for these difficulties with the astronomical theory. A reasonable explanation has been developed, that solidifies the astronomical theory by explaining the rise and fall of ice ages in both eras. The solar power absorbed at high northern latitudes depends on the insolation and absorptivity of the surface. The absorptivity is particularly affected by the obliquity in the pre-MPT era, and by dust deposits late in the post-MPT era. When these are included, it can be explained why some down lobes produce ice ages, and some up lobes produce terminations in both eras. In the pre-MPT era, ice ages originate when the insolation enters a down lobe and the obliquity is minimal (higher reflectivity) and ice ages terminate at a coincidence of high insolation and high obliquity (lower reflectivity). These links between SIHL and obliquity tend to be repetitive with approximately 41,000-year spacing. In the post-MPT era, ice ages also originate at a down lobe of SIHL. However, once an ice age is started, each successive up lobe in SIHL might cause a slight decrease in ice volume but doesn’t bring about a termination. After several precession cycles, high dust levels increase absorptivity, and the next-up lobe produces a termination.Read more

The Aral Sea is located in the heart of Asia, in Central Asia, spanning the western part of Kazakhstan and the northwestern part of Uzbekistan. It is a transient lake that emerged in its current location approximately 600–700 years ago. Until the 1960s, the surface level of the Aral Sea continued to rise due to the inflow from the Amu Darya and Syr Darya rivers.

Since the initial identification of TBCK (formerly MGC16169) in 2010, significant advances have been made in understanding the role of TBCK mutations in neurodevelopmental disorders such as TBCK encephalopathy. However, the precise function and detailed mechanisms of TBCK remain largely unexplored. Previous studies, including our own, suggest that aberrant expression or mutations in TBCK can impact cell growth, division, and cytoskeleton assembly, contributing to both cancer and neurogenetic diseases. Despite this, the specific domains within T...BCK responsible for these functions are still unclear. Notably, mutations in the TBC domain have been implicated in disrupting mTOR pathways, linking TBCK dysfunction to neurogenetic disorders and cancers. Given TBCK’s diverse roles, we have focused on its putative kinase domain. Through comprehensive analysis using tools such as Kinase Tree, AlphaFold2, Clustal Omega, and SMART, we discovered that TBCK lacks the key “D” residue in the conserved “HRD” and “DFG” motifs typical of protein kinases like PKA and SRC, suggesting TBCK functions as a pseudokinase. Intriguingly, gene ontology analysis from recent RNA-seq data indicates TBCK’s involvement in regulating protein phosphorylation. This suggests that TBCK may influence protein phosphorylation either directly through its potential kinase domain or indirectly via interactions with other proteins. To uncover the full spectrum of TBCK’s roles in neurogenetic disorders and cancer, urgent high-throughput analyses are necessary to identify its interacting partners.Read more

The study evaluates the efficacy of leufenuron, emamectin benzoate, and thiamethoxam against the Dusky Cotton Bug (Oxycarenus laetus Kirby) using residue-based bioassay methods. Key findings indicate that emamectin benzoate showed the highest efficacy with the lowest LC50 value, making it the most potent insecticide among those tested. Leufenuron and thiamethoxam followed, displaying moderate effectiveness. The results highlight the comparative advantages of emamectin benzoate in controlling Dusky Cotton Bug populations, suggesting its potentia...l role in integrated pest management strategies. This study underscores the need for environmentally friendly alternatives to traditional insecticides in mitigating yield losses in cotton production.Read more

This research used the improved export coefficient model to estimate non-point source load in sub-watersheds and a self-organizing map model to identify the correlation relationship of factors, that can be affected by non-point source load in Yangtze River Basin. Research results indicate that total nitrogen load is 4.87 - 15.53 kg/ha; total phosphorus load is 0.18 - 0.51 kg/ha; Dong Ting Lake sub-basin has the lowest contribution value of total nitrogen and phosphorus; Tai Lake sub-basin has the highest contribution load of total nitrogen and ...total phosphorus; Jinsha River sub-basin reveals the highest value of total nitrogen and phosphorus contribution on grassy land and desert land; Tai Lake sub-basin has the highest total nitrogen and total phosphorus load on forest, agricultural land, and urban construction land. The correlation relationship of factors reveals a very close correlation with each other as precipitation, total nitrogen load, and total phosphorus load factors have correlation in the highest value, in which total nitrogen load and total phosphorus load factors have a close correlation with each other from the lowest value to highest value; wetland and barren land factors correlate with the lowest value and the highest value; agricultural land, forestland, and grassy land factors correlate with one another in the high value and the highest value. The forest cover rate factor, as well as the population factor, does not correlate with other factors.Read more

Recently, environmental pollution has acquired the character of a global environmental threat, the current situation causes concern for the authorities, scientists, and the public and the need to develop simple and sufficiently effective technologies for the return to nature of elements that have been re-formed in the course of economic processes and thus become pollutants.Traditionally used physical and chemical methods are effective, but very expensive and may cause additional load on ecosystems. Existing outdated technologies and equipment f...or wastewater treatment need to be replaced with new ones.Phytoremediation is a set of methods for treating wastewater, soil and atmospheric air with the help of green plants. Due to differences in plant physiology, not all plants can collect heavy metals or organic pollutants. Even varieties of the same species can accumulate pollutants.The work aims to investigate natural means of cleaning the environment by phytoremediation.Several field trials confirmed the possibility of using the Paulownia plant for cleaning the air environment of Almaty city. The results of the study showed that the fast-growing Paulownia tree in areas with heavy metal-contaminated cadmium, lead, arsenic and antimony polluted and disturbed soils can be rehabilitated or reclaimed.All advantages and limitations of the phytoremediation method were investigated and experimentally demonstrated. The obtained research results confirm the prospects of the phytoremediation method for reducing environmental impact on contaminated soils.Read more

Teledentistry, the use of telecommunication technology to provide dental care and consultation remotely, has gained significant traction in recent years, particularly accelerated by the COVID-19 pandemic. This article explores the various applications, benefits, challenges, and future directions of teledentistry in modern dental practice. Emphasis is placed on its role in improving access to care, enhancing patient education, and supporting dental professionals through remote consultations and collaborations.

Recent advancements in computer-assisted surgical navigation have enhanced imaging precision while reducing fluoroscopy reliance. However, integrating these systems into outpatient interventional pain practices remains costly. This paper investigates a cost-effective Augmented Reality (AR) navigation system tailored for image-guided spinal pain procedures. We verify the feasibility of AR in spinal surgery and the potential of AR to replace fluoroscopy.

Mastocytosis, a hematological neoplasm, manifests with diverse clinical, molecular, and histomorphological features. This review explores the different subtypes of mastocytosis, focusing on the role of molecular pathology and histomorphology in diagnosing systemic mastocytosis (SM). Systemic mastocytosis is characterized by histologically confirmed extracutaneous involvement, presenting a diagnostic challenge due to its rarity and diverse subtypes, ranging from occult SM to mast cell leukemia. The complexity of accurate SM diagnosis underscores... the necessity for a comprehensive understanding of the disease spectrum. Mastocytosis emerges as a rare, multifaceted disease, predominantly affecting children in the cutaneous form and adults in the systemic variant. The review advocates a multidisciplinary diagnostic approach involving experienced hematopathologists and haematooncologists, employing conventional histomorphology, immunohistochemistry, and molecular techniques. This holistic approach is crucial for accurate diagnosis, especially in light of recent therapeutic advances, particularly the growing importance of tyrosine kinase inhibitors (TKI) in the management of mastocytosis.Read more